Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells
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چکیده
منابع مشابه
Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia
B acute lymphoblastic leukemia (B-ALL) cells are distinctively vulnerable to endoplasmic reticulum (ER) stress. Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma. We investigated the role of a novel, orally available, p97 inhibitor (CB-5083; Cleave Biosciences) in B-ALL. CB-5083 induced a significant reduction in viabil...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2020
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2020.1754584